Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms
- Author:
Jun-ying JIA
1
;
Er-huan ZANG
2
;
Qin-yu LI
2
;
Chun-hua ZHANG
2
;
Min-hui LI
2
;
Li-juan LV
3
;
Ying XIA
4
;
Min-hui LI
4
;
Lei ZHANG
5
;
Min-hui LI
5
;
Lian-sheng DANG
6
;
Min-hui LI
7
Author Information
- Publication Type:Journal Article
- Keywords: anti-apoptosis; anti-inflammation; antioxidant activity; flavonoids; myocardial ischemia-reperfusion injury
- From: Chinese Herbal Medicines 2021;13(1):49-63
- CountryChina
- Language:Chinese
- Abstract: Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties; They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury (MIRI). In this review, we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e) myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.
