Daphnane-type diterpenes from genus Daphne and their anti-tumor activity
10.1016/j.chmed.2020.09.006
- Author:
Zi-lin HOU
1
;
Guo-dong YAO
1
;
Shao-jiang SONG
1
Author Information
1. Liaoning Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
anti-tumor effect;
bcompound structure;
Daphnane-type diterpenes;
Daphne genus;
molecular mechanism
- From:
Chinese Herbal Medicines
2021;13(2):145-156
- CountryChina
- Language:Chinese
-
Abstract:
Daphnane-type diterpenenoids are the major biologically active constituents in the genus Daphne. We find that there are about 101 Daphnane-type diterpenes in this genus, most of those compounds show different degrees of inhibitory effect on various cancer cell. Some of them have been studied in depth and the potent molecular mechanisms might be associated with modulation of different cell-signaling pathways. In addition, some compounds of this type also can inhibit the synthesis of protein and DNA. Absolutely, the anti-tumor activity of Daphnane-type diterpenes is worthy of attention. Unfortunately, most of the current research on the activity of these compounds is focused on simple drug efficacy, and its in-depth mechanism research is far from enough. On the other point of view, there still exists wide growing space on the depth of these compounds.
