A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
10.1016/j.chmed.2020.12.007
- Author:
Zu-hua WANG
1
;
Xue-yan SUN
1
;
Ting-ting FENG
1
;
Zhi-wei WANG
1
;
Ying ZHOU
1
;
Zu-hua WANG
2
;
Jiao-jiao ZHANG
2
;
Zhi-wei WANG
2
;
Jiao-jiao ZHANG
3
;
Francesca GIAMPIERI
3
;
Maurizio BATTINO
3
;
Francesca GIAMPIERI
4
;
Cheng-ju JIANG
5
;
Jiao-jiao ZHANG
6
;
Rong-yi CHEN
6
;
Maurizio BATTINO
7
Author Information
1. College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine
2. Nano-drug Technology Research Center of Guizhou University of Traditional Chinese Medicine
3. Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche
4. Department of Biochemistry, Faculty of Sciences, King Abdulaziz University
5. QianDongNan Vocational & Technical College for Nationalities
6. School of Medicine, Southern Medical University
7. International Research Center for Food Nutrition and Safety, Jiangsu University
- Publication Type:Journal Article
- Keywords:
anti-hypertrophic scar effect;
Chinese medicine;
hypertrophic scars;
ointment;
orthogonal design
- From:
Chinese Herbal Medicines
2021;13(2):210-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition (SCMC) ointment on the rabbit ear hypertrophic scar models. Methods: The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests. The SCMC ointment was prepared through emulsifying method. The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment. Results: Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements. Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading, and took an unobvious but palpable shift from hard to soft texture with the low, middle and high concentration SCMC ointments treatments in vivo. Additionally, on 21st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group, in a concentration-dependent manner. The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation. Conclusion: The SCMC ointment could improve the blood circulation condition of hypertrophic scar tissues. Our research has demonstrated the Chinese medicine composition ointment with good anti-hypertrophic scar properties that could be used to treat hypertrophic scars. Meanwhile, it provides a theoretical basis for further clinical application.
