Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea
10.1016/j.chmed.2020.11.004
- Author:
Saravanan JAYARAM
1
;
Deepa SUGUMAR
1
;
Emdormi RYMBAI
1
Author Information
1. Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research
- Collective Name:Department of Pharmacology, KMCH College of Pharmacy, Tamil Nadu Dr. M. G. R. Medical University
- Publication Type:Journal Article
- Keywords:
antioxidants;
Clitoria ternatea Linn.;
inflammation;
rheumatoid arthritis
- From:
Chinese Herbal Medicines
2021;13(2):243-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Clitoria ternatea is a well-known bioactive plant used to treat several inflammatory ailments in Ayurvedic system of medicine in India. The present investigation aimed to determine the anti-inflammatory and anti-arthritic activity of ethanolic extract of Clitoria ternatea roots (EECT) in animal models. Methods: The anti-inflammatory activity of the EECT was evaluated by carrageenan and histamine-induced paw edema. Results: EECT showed a significant reduction in mean paw edema volume in both carrageenan and histamine-induced inflammation. The efficacy of EECT in rheumatoid arthritis was tested against Freund's complete adjuvant (CFA) induced arthritic model in Wistar rats. The anti-arthritic effect of EECT was determined by systematic scoring of arthritis symptoms and measuring paw edema. A considerable decrease in paw diameter was observed in the EECT (200 and 400 mg/kg) and diclofenac (10 mg/kg) treated groups after day 7. Diclofenac (10 mg/kg) and EECT (400 mg/kg) showed a significant reduction in paw diameter from day 14 compared with CFA control (P < 0.001). The anti-arthritic activity was also confirmed from the altered biochemical, haematological (Hb, RBC and WBC) and anti-oxidant parameters (SOD, MDA, CAT, and GSH). EECT (400 and 200 mg/kg) also showed a marked inhibition of joint destruction. Conclusion: This study provides a pharmacological rationale for the traditional use of C. ternatea against inflammation and rheumatoid arthritis in India.
