Polyphenols from Securidaca inappendiculata alleviated acute lung injury in rats by inhibiting oxidative stress sensitive pathways
10.1016/j.chmed.2020.09.007
- Author:
Cong-lan JI
1
;
Sheng DAI
1
;
Hong LIU
1
;
Ji-yang DONG
2
;
Chun-sheng LIU
3
;
Jian ZUO
3
;
Jian ZUO
4
;
Jian ZUO
5
Author Information
1. Department of Pharmacy, Anhui College of Traditional Chinese Medicine
2. Department of Electronic Science, Xiamen University
3. Yijishan Hospital, Wannan Medical College
4. Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College)
5. Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui (Wannan Medical College)
- Publication Type:Journal Article
- Keywords:
antioxidant;
polyphenols;
reactive oxygen species (ROS);
Securidaca inappendiculata Hassk;
TLR4/NF-κB
- From:
Chinese Herbal Medicines
2021;13(3):381-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Securidaca inappendiculata is a medicinal plant frequently used in the treatment of inflammatory diseases in south China. In this study, we aimed to explore its bioactive constituent which contributes to the anti-inflammatory activity. Methods: Polyphenol-enriched and polyphenol-deprived fractions (PRF and PDF, respectively) were separated from the ethanolic extract by HPD300 macroporous resin-based method, and their anti-inflammatory activities were investigated on a lipopolysaccharide (LPS)-induced acute lung injury (ALI) model in rats. The possible mechanism of action in alleviating acute inflammation was studied using RAW264.7 cells. Results: Both Folin-Ciocalteu and
