Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis
10.1016/j.chmed.2021.09.005
- Author:
Yu-fei HE
1
;
Chu-tian MAI
1
;
Hu-dan PAN
1
;
Liang LIU
1
;
Hua ZHOU
1
;
Ying XIE
1
Author Information
1. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology
- Publication Type:Journal Article
- Keywords:
immune cells;
immunometabolism;
natural compounds;
rheumatoid arthritis;
traditional Chinese medicines
- From:
Chinese Herbal Medicines
2021;13(4):451-460
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA), the most common inflammatory arthropathy word wild, is a systemic autoimmune disease that mainly affects the synovium of joints with a high disability rate. Metabolic mis-regulation has emerged as a fundamental pathogenesis of RA linked to immune cell dysfunction, while targeting immunometabolism provides a new and effective approach to regulate the immune responses and thus alleviate the symptom of RA. Recently, natural active compounds from traditional Chinese medicines (TCMs) have potential therapeutic effects on RA and regulating immunometabolism. In this review, in addition to updating the connection between cellular metabolism and cell function in immune cells of RA, we summarized that the anti-inflammatory mechanisms of the potential natural compounds from TCM by targeting metabolic reprogramming of immune cells, and discusses them as a rich resource for providing the new potential paradigm for the treatment of RA.
