Analgesic alkaloids from Urticae Fissae Herba
10.1016/j.chmed.2021.09.008
- Author:
Xiaoru FENG
1
;
Yan CHEN
1
;
Xiaobo LI
1
;
Mengyue WANG
1
;
Peijun JU
2
Author Information
1. School of Pharmacy, Shanghai Jiao Tong University
2. Shanghai Key Laboratory of Psychotic Disorders
- Publication Type:Journal Article
- Keywords:
analgesic activity;
pyrrole alkaloid;
Urticae Fissae Herba
- From:
Chinese Herbal Medicines
2022;14(1):125-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the analgesic substances in the aerial part of Urtica fissa (Urticae Fissae Herba), commonly used for rheumatoid and rheumatism arthritis. Methods: The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models, and identified by comprehensive spectroscopic analysis. Results: Thirteen alkaloids (1–13), two lignans (14, 15), and three amides (16–18) were isolated from the active fractions. Among them, compound 1 was a new alkaloid, and compound 6 was a new natural product. The activity evaluation in vivo indicated that various pyrrole alkaloids (1, 3, 6, and 12) possessed significant analgesic activities, they could significantly inhibit the mice pain response induced by acetic acid and hot plate at the dosage of 2 mg/kg BW. Conclusion: The study revealed that the pyrrole alkaloids played important roles in the analgesic activities of Urticae Fissae Herba.
