Anticancer Effect of Selenium.
10.12771/emj.2017.40.1.17
- Author:
Joohyun WOO
1
;
Woosung LIM
Author Information
1. Department of Surgery, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea. limw@ewha.ac.kr
- Publication Type:Meta-Analysis ; Review
- Keywords:
Selenium;
Chemoprevention;
Neoplasms
- MeSH:
Animals;
Apoptosis;
Cell Cycle;
Chemoprevention;
DNA Damage;
Follow-Up Studies;
Heart Diseases;
Humans;
Selenium*
- From:The Ewha Medical Journal
2017;40(1):17-21
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Selenium is an essential microelement in animals including human. Selenium plays an important role in cellular functions such as deoxygenation and detoxification. Also, it can be used in treatment of cardiac disease, hepatic disease, AIDS and various cancers. Recent meta-analysis showed that high selenium exposure was associated with decreased risk of several cancers. Selenium has an effect on anticarcinogesis through several mechanisms, which are regulation of cell cycles, apoptosis, DNA damage and repair, inhibition of cellular adhesion and migration, anti-angiogenesis and immune modulation. Even though many laboratory studies have provided convincing evidence of these mechanisms, results from epidemiologic and clinical studies of selenium does not coincide with each other. Well-designed trials considering dosage and chemical form of selenium supplement as well as confounding factors and long-term follow-up of them would be needed to use selenium in chemoprevention and therapy of cancers.
