Xiaoke Decoction in treatment of type II diabetes: A Meta-analysis
10.1016/j.chmed.2021.08.004
- Author:
Baochang ZHOU
1
;
Cunxia REN
1
;
Minhui LI
1
;
Wenfang GUO
2
;
Minhui LI
2
;
Guoqing ZHANG
3
;
Minhui LI
3
;
Minhui LI
4
;
Minhui LI
5
;
Minhui LI
6
;
Minhui LI
7
Author Information
1. Inner Mongolia Medical University
2. Inner Mongolia Institute of Traditional Chinese Medicine
3. Inner Mongolia Hospital Of Traditional Chinese Medicine
4. Baotou Medical College
5. Guangxi Botanical Garden of Medicinal Plants
6. Qiqihar Medical University
7. Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources and Utilization, Baotou Medical College
- Publication Type:Journal Article
- Keywords:
Meta-analysis;
type II diabetes;
Xiaoke Decoction
- From:
Chinese Herbal Medicines
2022;14(1):130-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To systematically evaluate the clinical effect of Xiaoke Decoction in the treatment of type 2 diabetes. Methods: Chinese databases such as CNKI, Wanfang, Weipu Chinese Biomedical Journal Database, and Chinese Medical Biological Literature Database, PubMed, Cochrane Library, Embase, and Web of Science were searched for English language literature from their inception until November 2019. A Meta-analysis was performed using RevMan 5.3 and Stata 12.0. Results: Thirty-eight studies were included in this study, with a total of 3757 patients. It was found that adding Xiaoke Decoction could improve total efficiency. The Xiaoke Decoction groups surpassed the western medicine groups regarding improvement in total efficiency (OR = 3.49; 95% CI: 2.78–4.39, P < 0.00001). Adding Xiaoke Decoction could lower the fasting plasma glucose (FPG) level. The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in FPG levels (MD = −1.14; 95% CI: −1.36 to 0.92, P < 0.00001). Adding Xiaoke Decoction could lower the 2 h postprandial blood glucose (2hPG) level. The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in 2hPG (MD = −1.40; 95% CI: −1.61 to 1.19, P < 0.00001). Adding Xiaoke Decoction could lower glycated hemoglobin (HbA1c). The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in HbA1c (MD = −0.77; 95% CI: −0.95 to 0.58, P < 0.00001). It was found that adding Xiaoke Decoction could lower the traditional Chinese medicine (TCM) syndrome score. The TCM syndrome scores among patients in the Xiaoke Decoction group were lower than those among patients in the control group after treatment (MD = −4.90; 95% CI: −7.22 to 2.57, P < 0.0001). At the same time, we conducted a subgroup and sensitivity analysis of age and intervention duration on the heterogeneity of total efficiency, FPG, 2hPG, HbAlc, and TCM syndrome score outcome indicators. For detecting publication bias, an egger test was conducted. Conclusion: Compared with western medicine alone, Xiaoke Decoction has more advantages for the treatment of type 2 diabetes with respect to total efficiency, FPG, 2hPG, HbAlc, and TCM syndrome score.
