Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome

Author: Yingying HUANG ¹ ; Lihua XU ¹ ; Fangping ZHANG ¹ ; Yang LIU ¹ ; Yunyu WANG ¹ ; Fangfeng MENG ¹ ; Shuang LI ¹ ; Xintao CHENG ¹ ; Yuefeng BI ¹ ; Yang LIU ² ; Yuefeng BI ²
Author Information

1. School of Pharmaceutical Sciences, Zhengzhou University
2. Collaborative Innovation Center of New Drug Research and Safety Evaluation
Publication Type:Journal Article
Keywords: bioavailabilit; intestinal absorption; linarin; liposome; pharmacokinetics; solid dispersion
From: Chinese Herbal Medicines 2022;14(2):310-316
CountryChina
Language:Chinese
Abstract: Objective: The current investigation aimed to determine the appropriate dosage form by comparing solid dispersion and liposome to achieve the purpose of improving the solubility and bioavailability of linarin. Methods: Linarin solid dispersion (LSD) and linarin liposome (LL) were developed via the solvent method and the thin film hydration method respectively. The Transwell chamber model of Caco-2 cells was established to evaluate the absorption of drug. The pharmacokinetics of linarin, LSD and LL in rats after ig administration were carried out by high performance liquid chromatography (HPLC) method. Results: The solubility of LSD and LL was severally 3.29 times and 3.09 times than that of linarin. The permeation coefficients of LSD and LL were greater than 10