Molecular mechanisms of isoflavone puerarin against cardiovascular diseases: What we know and where we go
10.1016/j.chmed.2021.12.003
- Author:
Weida QIN
1
;
Jianghong GUO
1
;
Wenfeng GOU
1
;
Shaohua WU
1
;
Wenbin HOU
1
;
Weida QIN
2
;
Shaohua WU
2
;
Wenbin HOU
2
;
Na GUO
3
;
Yuping ZHAO
3
Author Information
1. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences
2. Tianjin University of Traditional Chinese Medicine
3. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
cardiovascular disease;
molecular mechanism;
puerarin;
signaling pathways
- From:
Chinese Herbal Medicines
2022;14(2):234-243
- CountryChina
- Language:Chinese
-
Abstract:
Puerarin (Pue), known as a phytoestrogen, has salient bioactivities and is promising against cardiovascular diseases. This article summarizes the underlying molecular mechanisms of Pue in treating cardiovascular diseases, especially regulating the intracellular signal transduction, influencing ion channels, modulating the expression of microRNA, and impacting on the autophagy, which are mainly involved in the inflammatory signaling pathways, fatty acid/lipid metabolism, oxidative stress, apoptosis, and the like. The protective effect of Pue against cardiovascular diseases mainly involves attenuating the myocardial injury and decreasing the myocardial fibrosis, improving the myocardial ischemia/reperfusion injury, as well as inhibiting the myocardial hypertrophy and atherosclerosis. The molecular mechanisms of Pue's cardiovascular protective effects for the first time and comment on the state-of-the-art research methods and principles of Pue's regulation of small molecules were reviewed, so as to provide the rationale for its basic research and clinical applications.
