Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation
10.1016/j.chmed.2022.06.003
- Author:
Shuyin BAO
1
;
Qianqian MA
1
;
Chengxi WEI
1
;
Shuyin BAO
2
;
Qianqian MA
2
;
Chengxi WEI
2
;
Xiuzhi WANG
3
;
Shuyin BAO
4
;
Jixing NAN
4
;
Wuliji AO
5
;
Wuliji AO
6
Author Information
1. Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University
2. Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System
3. Department of Medicines and Foods, Tongliao Vocational College
4. Jilin Key Laboratory for Traditional Chinese Korean Medicine, College of Pharmacy, Yanbian University
5. Research and development center, Inner Mongolia Research Institute of Traditional Mongolian Medicine Engineering Technology
6. Mongolian Medicine R&D National Local Union Engineering Research Center, Inner Mongolia Minzu University
- Publication Type:Journal Article
- Keywords:
Mongolian medicine;
nonalcoholic fatty liver disease;
type 2 diabetes mellitus;
Xike Rixijing Disease
- From:
Chinese Herbal Medicines
2022;14(3):367-375
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are the most problematic metabolic diseases in the world. NAFLD encompasses a spectrum of severity, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis, increasing the risk of cirrhosis and hepatocellular carcinoma. Importantly, NAFLD is closely linked to obesity and tightly interrelated with insulin resistance and T2DM. T2DM and NAFLD (T2DM-NAFLD) are called as the Xike Rixijing Disease and Tonglaga Indigestion Disease respectively, in Mongolian medicine. Xike Rixijing Disease maybe develop into Tonglaga Indigestion Disease. Forturnately many Mongolian medicines show efficient treatment of T2DM-NAFLD, such as Agriophyllum squarrosum, Haliyasu (dried powder of camel placenta), Digeda-4 (herbs of Lomatogonium carinthiacum, rhizomata of Coptis chinensis, ripe fruits of Gardenia jasminoides, herbs of Dianthus superbus), Guangmingyan Siwei Decoction Powder (Halite, ripe fruits of Terminalia chebula, rhizomata of Zingiber officinale, fruit clusters of Piper longum), Tonglaga-5 (ripe fruits of Punica granatum, barks of Cinnamomum cassia, ripe fruits of Amomum kravanh, fruit clusters of Piper longum, flowers of Carthamus tinctorius), Tegexidegeqi (rhizomata of Inula helenium, ripe fruits of Gardenia jasminoides, rhizomata of Platycodon grandiflorum, rhizomata of Coptis chinensis, heartwood of Caesalpinia sappan), Ligan Shiliu Bawei San (ripe fruits of Punica granatum, barks of Cinnamomum cassia, ripe fruits of Amomum kravanh, fruit clusters of Piper longum, flowers of Carthamus tinctorius, ripe fruits of Amomum tsao-ko, rhizomata of Zingiber officinale), etc. Principles of Mongolian medicine in treating diseases: by balancing “three essences or roots” and “seven elements”, strengthening liver and kidney function, transporting nutrients to enhance physical strength and disease resistance, and combined with drugs for comprehensive conditioning treatment. However, their molecular mechanisms remain unclear. In this review, we prospect that Mongolian medicines might be a promising treatment for T2DM-NAFLD by activating P2X7R/NLRP3/NF-κB inflammatory pathway via lipid-sensitive nuclear receptors (i.e., FXR and LXR).
