Camganoids A and B, two new sesquiterpenes with different carbon skeletons isolated from fruits of Cinnamomum migao
10.1016/j.chmed.2021.09.016
- Author:
Yongzhen XIAO
1
;
Ishaq MUHAMMAD
1
;
Shikai YAN
1
;
Huizi JIN
1
;
Shikai YAN
2
;
Huizi JIN
2
;
Xianpeng MA
3
;
Huajun YU
3
;
Xue XIAO
4
Author Information
1. Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University
2. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University
3. Guizhou Jingcheng Pharmaceutical Co., Ltd.
4. Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
Cinnamomum migao H. W. Li;
nitric oxide inhibition;
sesquiterpene
- From:
Chinese Herbal Medicines
2022;14(4):638-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To isolate and identify the undescribed compounds from the fruits of Cinnamomum migao and evaluate its nitric oxide inhibition potential. Methods: The chromatographic techniques of silica gel, Sephadex, and HPLC were used for isolation and purification of the compounds, while HR-ESI-MS, 1D NMR, 2D NMR, ECD, and X-ray diffraction techniques were used to characterize and confirm the isolated compounds. Moreover, the anti-inflammatory activity of the isolated compounds was carried out to check inhibitory potential against the production of nitric oxide with RAW264.7 cells stimulated by LPS. Results: Camganoid A (1), a novel sesquiterpene possessing an unprecedented skeleton, and camganoid B (2), containing a unique eight-membered sesquiterpene moiety with a new carbon skeleton, were isolated and identified from the fruits of C. migao. The absolute configurations of 1 and 2 were confirmed by single crystal X-ray diffraction and electronic circular dichroism (ECD) calculations. Among these compounds, compound 1 exhibited potent inhibitory activity against the production of nitric oxide with IC
