Molecular mechanisms of anti-cancer bioactivities of seaweed polysaccharides

Author: Tingting LIU ¹ ; Guoxia LI ¹ ; Qing LI ² ; Xu XU ² ; Chengwang TIAN ² ; Tiejun ZHANG ² ; Qing LI ³ ; Xu XU ³ ; Chengwang TIAN ³ ; Tiejun ZHANG ³ ; Chengwang TIAN ⁴ ; Tiejun ZHANG ⁴
Author Information

1. School of Basic Medicine, Tianjin Medical University
2. Tianjin Pharmaceutical Research Institute
3. State Key Laboratory of Drug Release Technology and Pharmacokinetics
4. Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences
Publication Type:Journal Article
Keywords: anti-cancer; apoptosis; immunomodulation; seaweed polysaccharides; signal pathways
From: Chinese Herbal Medicines 2022;14(4):528-534
CountryChina
Language:Chinese
Abstract: Seaweed is a traditional Chinese medicine homologous to food, in which polysaccharides are responsible for anti-cancer by enhancing immunity, inducing cancer cell apoptosis, inhibiting cancer cell invasion and metastasis or directly scavenging oxidative free radicals that induce cancer cell changes. Among them, regulating immunity and promoting cancer cell apoptosis are intensively studied due to the important role in preventing cancer. Here we reviewed seaweed in the apoptosis-inducing signaling pathways including PI3K/AKT, ROS and JNK and discussed challenges in studying seaweed.