Vacuum-assisted venous drainage in adult open-heart surgery: A randomized controlled trial
- VernacularTitle:体外循环心脏直视手术中负压调节器辅助静脉引流的随机对照试验
- Author:
Gang LIU
1
;
Sizhe GAO
1
;
Jian WANG
1
;
Chun ZHOU
1
;
Shujie YAN
1
;
Qian WANG
1
;
Yuan TENG
1
;
Yan LIU
2
;
Yu CHEN
3
,
4
;
Bingyang JI
1
Author Information
1. Department of Cardiopulmonary Bypass, Fuwai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100037, P. R. China
2. Department of Cardiopulmonary Bypass, Wuhan Asia Heart Hospital, Wuhan, 430022, P. R. China
3. Department of Cardiac Surgery, Peking University People&rsquo
4. s Hospital, Beijing, 100044, P. R. China
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
vacuum-assisted venous drainage;
cardiac surgery;
randomized controlled trial
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(11):1460-1465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the safety and efficacy of vacuum-assisted venous drainage (VAVD) in cardiac surgery under cardiopulmonary bypass (CPB). Methods A total of 180 patients from 3 centers between November 17, 2017 and October 1, 2018 were enrolled and randomly assigned to a VAVD group and a gravity drainage (GD) group by 1∶1 ratio. During the open-heart surgery under CPB, the VAVD group completely relied on VAVD, and the GD group used conventional GD. The primary endpoint was arterial flow before CPB, 15 min after aortic cross-clamping and rewarming to 36 °C of nasopharyngeal temperature. The secondary endpoints included hematocrit, hemoglobin concentration, blood product transfusion, etc. The safety endpoint was free hemoglobin concentration, etc. Results The full analysis set contained 175 patients, 87 in the VAVD group and 88 in the GD group. Patients in the VAVD group were aged 52.8±12.0 years, and males accounted for 55.2%; patients in the GD group were aged 51.4±12.1 years, and males accounted for 59.1%. The demographic characteristics between the two groups were not statistically different. Compared to the GD group, the VAVD group could provide comparable arterial flow in CPB [average of 3 time points, 2.37±0.22 L/(min·m2) vs. 2.41±0.25 L/(min·m2), P=0.271], while not elevating free hemoglobin concentration. Conclusion VAVD can provide enough venous drainage, while not elevating free hemoglobin concentration or damaging blood.
