Effect of Rehabilitation Training on Learning and Memory Ability and Long-term Potentiation in Rats with Bilateral Hippocampal Infarction.

VernacularTitle:康复训练对双侧海马梗死大鼠学习记忆能力与长时程增强的影响
Author: Yingzi ZHAO ; Xiaoming ZHANG ; Wei FANG ; Lijuan HE ; Zhen ZHANG
Publication Type:Journal Article
Keywords: rehabilitation training, bilateral hippocampal infarction, learning and memorial ability, long-term potentiation, rats
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(8):724-727
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of rehabilitation training on learning and memorial ability and long-term potentiation (LTP) in hippocampal region CA3 in rats with cerebral infarction. Methods 30 male rats were randomly divide into model group, rehabilitation training group and normal group with 10 cases in each group. Photochemical method was used to induce hippocampal infarction. The performance of Y-maze test and moving-back with current stimulation experiment were recorded. The increase rate of population spike (PS) in hippocampal region CA3 and PS latent period were compared. Results The frequency of training of Y-maze test was less after rehabilitation training, the latent period of moving-back with current stimulation experiment prolonged, and the PS latent period was shortened. Conclusion Rehabilitation training may strengthen the LTP effect in hippocampal region CA3, and improve the learning efficiency