Expression of Bcl-2 and P53 in Neonate Rats with White Matter Damage Induced by Lipopolysaccharide
- VernacularTitle:脂多糖致新生鼠脑白质损伤后Bcl-2和P53蛋白表达的变化
- Author:
Qingchun MA
;
Lin LI
- Publication Type:Journal Article
- Keywords:
whiter matter damage, Bcl-2, P53, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(3):240-242
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the change of Bcl-2 and P53 expresssion after whiter matter damage in neonatal rats. Methods100 rats (2 days old) were randomly divided into two groups: control group and periventricular leucumalacia (PVL) group. Control group received normal saline 5 mg/kg intraperitoneal injection, PVL group received lipopolysaccharide (LPS) 5 mg/kg intraperitoneal injection. The expression of Bcl-2 and P53 was measured 6 h, 12 h, 24 h, 48 h after operation with immunohistochemical staining. ResultsThe expression of Bcl-2 increased 6 h after operation, and to the top 48 h after operation in the PVL group, which was significantly different compared with the control group (P<0.01). The expression of P53 increased at 6 h after operation, and to the top 12 h after operation in the PVL group, which was significantly different compared with the control group (P<0.01). ConclusionThe expression of Bcl-2 and P53 increased in the white matter injuried neonatal rats induced by LPS.
