Establishing the Rat Model of Multi-infarct Dementia
- VernacularTitle:大鼠脑多梗死性痴呆模型的建立
- Author:
Donghui WU
;
Jinfeng HU
;
Zhipeng LI
;
Haijie JI
;
Naihong CHEN
- Publication Type:Journal Article
- Keywords:
multi-infarct dementia, sephadex, model, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(3):232-234
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo establish the rat model of multi-infarct dementia. MethodsSephadex (4 mg/ml, 8 mg/ml) was injected into the internal carotid artery through the common carotid artery. Neurological deficits were measured 24 h after the operation, and Morris water maze test as well as Nissl stain were observed 26～30 d after the operation. ResultsThere was significant difference between the model groups injected sephadex of 8 ml/ml and 4 mg/ml in the neurologic deficits. In the following experiment, the rats injected sephadex of 8 mg/ml were only used as model. For the water maze test, the escape latency was longer (P＜0.01) and the frequency across target area reduced (P＜0.01) in the model, while the apoptotic Nissl body could be observed. ConclusionA model of multi-infarct dementia could be established with the sephadex in rats.
