Simvastation for Transient Ischemic Attack following Carotid Atherosclerosis
- VernacularTitle:辛伐他汀治疗短暂性脑缺血发作患者颈动脉粥样硬化斑块的临床观察
- Author:
Donglin HAO
;
Xiaonan CHEN
;
Lihui WANG
;
Baozhen CHEN
- Publication Type:Journal Article
- Keywords:
simvastatin, transient ischemic attack, carotid atherosclerosis
- From:
Chinese Journal of Rehabilitation Theory and Practice
2011;17(2):163-164
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effects of simvastatin on patients with transient ischemic attack (TIA) following carotid atherosclerotic plaque.Methods96 cases of TIA patients with carotid atherosclerosis plaque were randomly divided into simvastatin (statins) group and control group, 48 cases in each group. The statins group took simvastatin except routine therapy for 6 months, while the control group took Xuezhikang. The ultrasonic examination of carotid artery intima-media thickness (IMT) and atherosclerosis area were carried out before and after treatment for both groups. The incident rates of cerebral vascular diseases within 6 months were compared between two groups.ResultsThe ultrasonic examination showed significantly thinning of carotid IMT and reducing of plaque area in statins group (P<0.05), while there wasn't significant difference in control group(P>0.05). The cerebral vascular incident rates in statins group were lower than in control group(P<0.05).ConclusionSimvastatin may be more effective for antiatherosclerotic function with bigger dosage and decrease ischemic cerebral vascular incidence.
