Association between postpartum depression and concentrations of transforming growth factor-β in human colostrum: a nested cohort study.
10.12122/j.issn.1673-4254.2022.09.21
- Author:
Zi Yu XIONG
1
;
Le Peng ZHOU
1
;
Jing Fen CHEN
1
;
Meng LI
2
;
Ri Hua XIE
1
Author Information
1. Department of Nursing, Southern Medical University, Foshan 528244, China.
2. Department of Obstetrics, The Seventh Affiliated Hospital, Southern Medical University, Foshan 528244, China.
- Publication Type:Journal Article
- Keywords:
Edinburgh Postnatal Depression Scale;
human colostrum;
nested cohort study;
postpartum depression;
transforming growth factor-β
- MeSH:
Child, Preschool;
Cohort Studies;
Colostrum;
Depression, Postpartum/diagnosis*;
Female;
Humans;
Infant;
Postpartum Period;
Pregnancy;
Transforming Growth Factor beta1;
Transforming Growth Factor beta2;
Transforming Growth Factor beta3;
Transforming Growth Factors
- From:
Journal of Southern Medical University
2022;42(9):1426-1430
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association between postpartum depression (PPD) and transforming growth factor-β (TGF-β) concentrations in human colostrum.
METHODS:Participants were recruited from a maternal and infant cohort established in a tertiary general hospital in Guangdong Province between December, 2020 and September, 2021. In the afternoon of the second postpartum day, the women were evaluated with Edinburgh Postnatal Depression Scale (EPDS) for screening PPD (defined as a score of 10 or higher). The women with PPD were matched at a 1:1 ratio with women without PPD with maternal age difference within 5 years and the same mode of delivery. Colostrum samples were collected in morning on the third postpartum day for measurement of TGF-β concentrations using enzyme-linked immunosorbent assay (ELISA), and the association between EPDS scores and TGF-β concentrations was analyzed in the two groups.
RESULTS:A total of 90 women were included in the final analysis. The mean concentrations of TGF-β1, TGF-β2 and TGF-β3 in the colostrum were 684.03 (321.22-859.25) pg/mL, 5116.50±1747.04 pg/mL and 147.84±48.68 pg/mL in women with PPD, respectively, as compared with 745.67 (596.00-964.22) pg/mL, 4912.40±1516.80 pg/mL, and 168.21±48.15 pg/mL in women without PPD, respectively. Compared with women without PPD, the women with PPD had significantly lower concentrations of TGF-β1 (P=0.026) and TGF-β3 (P=0.049) in the colostrum. Spearman correlation analysis revealed that the EPDS scores were negatively associated with the concentrations of TGF-β1 (r=-0.23, P=0.03) and TGF-β3 (r=-0.25, P=0.02) in the colostrum.
CONCLUSION:PPD is associated with decreased concentrations of TGF-β1 and TGF-β3 in human colostrum, suggesting the need of early PPD screening and interventions during pregnancy and the perinatal period to minimize the impact of PPD on human milk compositions.
