Comparative Analysis between Sextant Biopsy and 12-samples Needle Biopsy for Detection of Stage T1c Prostate Cancer.
- Author:
Kwan Sik BAE
1
;
Sung Goo CHANG
Author Information
1. Department of Urology, School of Medicine, Kyung Hee University, Seoul, Korea. sgchang@khu.ac.kr
- Publication Type:Original Article
- Keywords:
Prostate cancer;
Biopsy;
Prostate-specific antigen
- MeSH:
Anesthesia, Local;
Biopsy*;
Biopsy, Needle*;
Digital Rectal Examination;
Humans;
Incidence;
Needles*;
Prostate*;
Prostate-Specific Antigen;
Prostatic Neoplasms*
- From:Korean Journal of Urology
2004;45(7):653-657
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The incidence of stage T1c prostate cancer has been reported to have increased more than any other prostate cancer. To evaluate whether a sextant biopsy is useful for the detection of stage T1c prostate cancer, the detection rates were compared between the sextant and 12-sample needle biopsies, in relation to the prostate volume (PV) and serum prostate specific antigen (PSA) level. MATERIALS AND METHODS: Between January, 1986 and December, 2002, 123 patients who were found to be normal upon digital rectal examination, with negative findings on a transrectal ultra sonography (TRUS) examination and elevated serum PSA (>4ng/ml), underwent either a sextant or 12-sample needle biopsy, under local anesthesia, to detect the presence of prostate cancer. RESULTS: There was no statistically significant difference in the cancer detection rate between the sextant (11/41) and 12-sample (24/82) needle biopsies of the prostate. According to the total PSA level, the detection rates of prostate cancer for the 6 and 12 core groups were 31.6 (6/19) and 22.8% (8/35), respectively, (PSA: 4.1-9.9ng/ml), 23.1 (3/13) and 32.0% (8/25) (PSA: 10.0-19.9ng/ml), and 22.2 (2/9) and 36.4% (8/22) (PSA >or=20.0ng/ml). According to the prostate volume, the detection rates of prostate cancer for the 6 and 12 core groups were 28.6 (2/7) and 31.0% (9/29), respectively (PVor=60ml). Our study did not have the statistical power required to rule out small differences. CONCLUSIONS: These findings imply that a sextant biopsy constitutes a useful method for the detection of prostate cancer.
