68Ga-PSMA-I&T PET/CT for assessment of tumor burden in primary lesions of treatmentnaïve prostate cancer.
10.12122/j.issn.1673-4254.2022.08.05
- Author:
Yan XIE
1
;
Cheng LI
2
;
Lu Lu ZHANG
1
;
Shi Ming ZANG
1
;
Fei YU
1
;
Shi Ming WANG
3
;
Fei WANG
1
Author Information
1. Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
2. Department of Nuclear Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China.
3. Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
- Publication Type:Journal Article
- Keywords:
68Ga-PSMA-I&T;
metastasis risk;
prostate cancer;
prostate specific membrane antigen;
risk stratification;
tumor load
- MeSH:
Aged;
Aged, 80 and over;
Edetic Acid;
Gallium Isotopes;
Gallium Radioisotopes;
Humans;
Male;
Middle Aged;
Oligopeptides;
Positron Emission Tomography Computed Tomography;
Prostate-Specific Antigen;
Prostatic Neoplasms/pathology*;
Retrospective Studies;
Tumor Burden
- From:
Journal of Southern Medical University
2022;42(8):1143-1148
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the value of 68Ga-labeled prostate specific membrane antigen (PSMA) PET/CT for assessing tumor load in primary lesions for risk stratification and predicting metastasis of newly diagnosed prostate cancer (PCa).
METHODS:We retrospectively analyzed the data of 36 patients (mean age 71.3 ± 8.6 years, range 56 to 89 years) with newly diagnosed PCa undergoing 68Ga-PSMA-I&T PET/CT from June 2018 to July 2019. SUVmax and SUVmean of the primary lesions were measured, and the primary PSMA tumor volume (PSMA-TV) and total lesion PSMA (TL-PSMA) were automatically measured and calculated in all the patients. The correlations of primary SUVmax, PSMA-TV, and TL-PSMA with PSA and Gleason score (GS) were analyzed, and SUVmax, PSMA-TV and TL-PSMA of the primary lesions were compared among different PCa subgroups.
RESULTS:SUVmax, PSMA-TV and TL-PSMA of the primary lesions were all correlated with PSA and GS (P < 0.05). PCa subgroup analysis showed that SUVmax, PSMA-TV and TL-PSMA were all significantly higher in patients with PSA >20 ng/mL than in those with PSA ≤20 ng/mL (P < 0.001), and were higher in patients with a GS ≥8 than in those with a GS ≤7 (P < 0.001). PSMA-TV and TL-PSMA were significantly higher in patients with tumor metastasis than in those without metastasis (P < 0.001), while SUVmax did not differ significantly with tumor metastasis. SUVmax (P=0.002), PSMA-TV (P < 0.001), and TL-PSMA (P < 0.001) were all significantly higher in high-risk group than in low-to moderate-risk group.
CONCLUSION:PSMA-TV and TL-PSMA of 68Ga-PSMA-I&T PET/CT have potential value in predicting risk stratification and metastasis of newly diagnosed PCa.
