Effect of Asymptomatic Prostatitis in Prostate Needle Biopsies on the Serum Prostate Specific Antigen and Prostate Specific Antigen Density.
- Author:
Jung Hyun KIM
1
;
Young Min KIM
;
Ro Jung PARK
Author Information
1. Departments of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. eslee@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Prostatitis;
Prostate specific antigen
- MeSH:
Biopsy;
Biopsy, Needle*;
Digital Rectal Examination;
Humans;
Inflammation;
Male;
Needles*;
Prostate*;
Prostate-Specific Antigen*;
Prostatitis*
- From:Korean Journal of Urology
2004;45(7):658-662
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The relationship between morphological parameters of inflammation in prostatic tissue and the levels of serum prostate specific antigen (PSA) and prostate specific antigen density (PSAD) were investigated. MATERIALS AND METHODS: 95 prostate biopsies performed on 95 men with elevated serum PSA and/or abnormal digital rectal examinations of the prostate were reviewed. Of these, 42 malignant biopsies and 2 cases of clinical prostatitis were excluded. In the remaining 51 prostate biopsies, the extent of inflammation, aggressiveness of inflammation and presence of polymorphonuclear leukocytic infiltration were scored at both the acini and ducts. RESULTS: The mean serum PSA levels in grades 0, 1 and 2 for the extent of inflammation were 11.4, 8.5 and 9.3, respectively. The mean PSAD levels in these groups were 0.27, 0.17 and 0.17, respectively. The mean serum PSA levels in grades 0, 1 and 2 for the aggressiveness of inflammation were 9.2, 9.5 and 3.8, respectively. The mean PSAD levels in these groups were 0.19, 0.18 and 0.09, respectively. The mean serum PSA levels in the absence and presence of polymorphonuclear leukocytic infiltration were 8.8 and 9.13, respectively. The mean PSAD levels in these groups were 0.18 and 0.15, respectively. The mean serum PSA and PSAD levels were not significantly increased with the proportional increases in the morphological parameters of inflammation. CONCLUSIONS: The serum PSA and PSAD levels were found not to be significantly increased with proportional increases in the morphological parameters of inflammation in asymptomatic histological prostatitis. It is propose that asymptomatic inflammation in prostate tissue is not the reason for delayed repeat prostate biopsies.
