The role of continuous 48 h oropharyngeal pH monitoring in the diagnosis of laryngopharyngeal reflux disease.
10.3760/cma.j.cn115330-20220530-00318
- Author:
Zhe Zhe SUN
1
;
Gang WANG
2
;
Lei WANG
1
;
Ge Lin LI
3
;
Hong Dan LIU
1
;
Bao Wei LI
1
;
Hao Lun HAN
1
;
Ying ZHOU
1
;
Yi Yan ZHANG
1
;
Xiao Li ZHANG
1
;
Wei WU
4
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery of PLA Strategic Suport Force Medical Center, Beijing 100101, China.
2. Research Department 4 of PLA Strategic Suport Force Medical Center, Beijing 100101, China State Environmental Protection Key Laboratory of Environmental Sense Organ Stress and Health, Beijing 100101, China.
3. Department of Otorhinolaryngology Head and Neck Surgery of Beijing Friendship Hospital, Beijing 100050, China.
4. Department of Otorhinolaryngology Head and Neck Surgery of PLA Strategic Suport Force Medical Center, Beijing 100101, China State Environmental Protection Key Laboratory of Environmental Sense Organ Stress and Health, Beijing 100101, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Laryngopharyngeal Reflux/diagnosis*;
Hydrogen-Ion Concentration;
Hypopharynx;
Larynx
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2022;57(10):1191-1196
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the daily variation of LPR and the significance of 48-hour oropharyngeal pH monitoring in the diagnosis of LPRD. Methods: 72 subjects with suspected LPRD who were treated in our department from June 2018 to June 2021 were included. All patients were hospitalized to complete continuous 48-hour oropharyngeal Dx-pH monitoring. The consistency of Ryan index and W index and the correlation of various reflux parameters between the first and second 24-hour were compared. SPSS 24.0 was used for statistical analysis. Results: All 72 subjects successfully completed 48-hour oropharyngeal Dx-pH monitoring. Ryan index was positive in 11 cases (15.2%) in the first 24-hour, in 17 cases (23.6%) in the second 24-hour, in 5 cases (6.9%) both first and second, and in 23 cases (31.9%) in either 24-hour, Kappa=0.211 (P=0.064), 18 cases (25%) had inconsistent results of the first 24-hour and the second 24-hour, and there was no significant difference in the positive rate between the first and second (P=0.234). The number of positive cases in 48-hour monitoring increased by 109.1% compared with 24-hour monitoring.For W index, 49 cases (68.1%) were positive in the first 24-hourf 53 cases (73.6%) were positive in the second 24-hour, 42 cases (58.3%) were positive both first and second, and 58 cases (80.6%) were positive in either 24-hour, Kappa=0.477 (P<0.001), 16 cases (22.2%) had inconsistent results of the first and second, and there was no significant difference in the positive rate between the first and second (P=0.804). The number of positive cases in 48-hour monitoring increased by 18.4% compared with 24-hour monitoring. There was no significant difference in all the reflux parameters of first and second (P>0.05). The correlation comparison showed that the correlation of various reflux parameters in the upright position was lower than that in the supine position. Conclusion: Laryngeal reflux has daily variability. Extending the monitoring time of Dx-pH to 48-hour can help reduce the missed diagnosis caused by daily variability; the use of W index can reduce the influence of daily variability on the diagnostic results of LPRD.
