Surgical treatment of papillary thyroid carcinoma involving larynx and trachea.
10.3760/cma.j.cn115330-20220408-00177
- VernacularTitle:累及喉、气管的甲状腺乳头状癌的手术治疗分析
- Author:
Tong Liang XIA
1
;
Chen Yang XU
1
;
Dong Min WEI
1
;
Ye QIAN
1
;
Wen Ming LI
1
;
Xin Lang PAN
1
;
Da Peng LEI
1
Author Information
1. Department of Otorhinolaryngology, Qilu Hospital of Shandong University, National Health Commission Key Laboratory of Otorhinolaryngology (Shandong University), Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Larynx/surgery*;
Male;
Neoplasm Invasiveness;
Quality of Life;
Retrospective Studies;
Thyroid Cancer, Papillary/surgery*;
Thyroid Neoplasms/pathology*;
Trachea/surgery*
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2022;57(9):1059-1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the efficacy of surgical treatment of papillary thyroid carcinoma (PTC) involving larynx and trachea. Methods: A total of 1 436 cases of thyroid malignant tumors were admitted to the Department of Otolaryngology, Qilu Hospital of Shandong University from 2004 to 2019, including 110 cases of PTC involving larynx and trachea, and of which 105 cases with complete follow-up data were retrospectively analyzed. There were 42 males and 63 females, with a male/female ratio of 1∶1.5, aged from 28 to 81 years. All lesions involved trachea, including 11 cases involving both trachea and larynx. Of those 83 cases underwent laryngeal and airway wall tumor excision, and 22 cases underwent radical tumor excision plus laryngeal and trachea repair. Extubation rate was analyzed and the postoperative survival curve of patients was analyzed by Kaplan-Meier method. Results: Among 105 cases, 16 cases underwent tracheotomy and 12 cases were successfully extubated. The overall 3- 5- and 10-year survival rates were 100.0%, 86.4% and 72.5%, and the disease-free survival rates were 93.1%, 81.6% and 57.7%, respectively. There was significant difference in survival curve between the two groups (χ2=4.21, P=0.040). The 5-year and 10-year survival rates were 94.6% and 77.3% in laryngeal and tracheal tumor exclusion group, and 85.7% and 51.4% in the radical tumor resection group. There was no significant difference in the survival curves between the two groups (χ2=3.50, P=0.061). Conclusion: PTC patients with laryngeal and tracheal involvement can achieve long survival and good quality of life through reasonable surgical treatment.
