Diagnostic values of urinary citrate for kidney stones in patients with primary gout.
- Author:
Yu WANG
1
;
Hui Min ZHANG
2
;
Xue Rong DENG
1
;
Wei Wei LIU
3
;
Lu CHEN
4
;
Ning ZHAO
5
;
Xiao Hui ZHANG
1
;
Zhi Bo SONG
1
;
Yan GENG
1
;
Lan Lan JI
1
;
Yu WANG
2
;
Zhuo Li ZHANG
1
Author Information
1. Department of Rheumatology and Immunology, Peking University First Hospital, Beijing 100034, China.
2. Department of Nephrology, Peking University First Hospital, Beijing 100034, China.
3. Department of Internal General Medicine, Zhongjie Hospital, Cangzhou 061108, Hebei, China.
4. Department of Traditional Chinese Medicine, Aviation General Hospital of China Medical University, Beijing 100012, China.
5. Department of Acupuncture, Huguosi Traditional Chinese Medicine Hospital affiliated to Beijing University of Chinese Medicine, Beijing 100035, China.
- Publication Type:Journal Article
- Keywords:
Citrate;
Dual-energy computed tomography;
Gout;
Kidney stone;
Ultrasonography
- MeSH:
Humans;
Urinary Calculi;
Uric Acid/analysis*;
Citric Acid;
Kidney Calculi/diagnostic imaging*;
Gout/diagnostic imaging*;
Citrates;
Oxalates
- From:
Journal of Peking University(Health Sciences)
2022;54(6):1134-1140
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the relationship between 24 h urinary ion content and kidney stones, and to explore the diagnostic values of kidney stone in primary gout patients.
METHODS:Patients diagnosed with primary gout had ultrasound scanning of both feet and kidneys in Peking University First Hospital from Jan. 2020 to May 2021. Their clinical characteristics were compared between the positive and negative kidney stone groups, and the relationship between kidney stone and urinary ion composition were analyzed. Risk factors of kidney stone were analyzed. The explored diagnostic values were evaluated for urinary oxalate and citrate according with uric acid kidney stones by dual-energy computed tomography (DECT).
RESULTS:Among the 100 gouty patients, 80 patients had uric acid crystal deposition in lower joints of extremity by ultrasonography, 61 patients had kidney stone, and 34 had kidney uric acid stones by DECT. All the multiple kidney stones were proved as uric acid kidney stones by DECT. Compared with patients without kidney stone group proved by ultrasonography, patients with kidney stone had longer gouty duration [(48.7±26.6) months vs. (84.0±30.6) months, P=0.01], higher 24 h urinary oxalate [(20.1±9.6) mg vs. (28.6±20.7) mg, P=0.001] and lower 24 h urinary citrate [(506.3±315.4) mg vs. (355.7±219.6) mg, P=0.001]. Compared with the patients without kidney stone by DECT, the patients with uric acid kidney stone also had longer disease duration [(49.1±28.4) months vs. (108.3±72.2) months, P=0.001], higher 24 h urinary oxalate [(23.6±16.9) mg vs. (28.5±18.8) mg, P < 0.05], lower 24 h urinary citrate [(556.0±316.3) mg vs. (391.7±261.2) mg, P < 0.05], higher serum uric acid [(466.2±134.5) μmol/L vs. (517.2±18.1) μmol/L, P < 0.05] and higher 24 h urinary uric acid [(1 518.1±893.4) mg vs. (1 684.2±812.1) mg, P < 0.05]. Logistic regression analysis showed long gout disease duration (OR=1.229, 95%CI: 1.062-1.522, P < 0.05), high serum uric acid level (OR=1.137, 95%CI: 1.001-1.213, P=0.01), low 24 h urinary citrate (OR=0.821, 95%CI: 0.659-0.952, P=0.01) were all risk factors of kidney stones by ultrasonography. Also, long gout disease duration (OR=1.201, 95%CI: 1.101-1.437, P=0.005), high serum creatine uric level (OR=1.145, 95%CI: 1.001-1.182, P=0.04), low 24 h urinary citrate (OR=0.837, 95%CI: 0.739-0.931, P=0.02) were all risk factors of kidney uric acid stones by DECT.
CONCLUSION:Long disease duration and low 24 h urinary citrate were risk factors for kidney stones.
