Research advances on the mechanism of refractory healing of diabetic foot ulcer.
10.3760/cma.j.cn501225-20220227-00038
- VernacularTitle:糖尿病足溃疡难愈合机制研究进展
- Author:
Ning WANG
1
;
Shang JU
1
Author Information
1. Peripheral Vascular Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Diabetic Foot/metabolism*;
Wound Healing;
Glycation End Products, Advanced/metabolism*;
Diabetes Mellitus
- From:
Chinese Journal of Burns
2022;38(11):1085-1089
- CountryChina
- Language:Chinese
-
Abstract:
The number of patients with diabetic foot ulcer (DFU) has increased progressively year by year. Refractory DFU has brought great burden to the country and individuals. How to accelerate the healing of DFU has become the main emphasis of research. However currently, the mechanism of its refractory healing is not fully elucidated, and the correlation between the various mechanisms are not high. Therefore, its clinical standardization, and precise clinical diagnosis and treatment still face several challenges. Based on the progress of clinical research and basic research at home and abroad, this paper reviewed the specific mechanisms that lead to refractory DFU, with the focus on chronic inflammation, bacteria biofilm formation, high oxidative stress, growth factor inhibition, impaired microcirculation, and accumulation of advanced glycation end products.
