Research advances on the effects of RNA N6-methyladenosine modification in the relevant pathophysiological processes of wound repair.
10.3760/cma.j.cn501120-20210804-00267
- Author:
Xiao Xiao LIU
1
;
De Wu LIU
1
Author Information
1. Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
- Publication Type:Journal Article
- MeSH:
RNA/metabolism*;
Methylation;
Adenosine/metabolism*;
Methyltransferases/metabolism*
- From:
Chinese Journal of Burns
2022;38(10):989-993
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine (m6A) exists widely in eukaryotes as a post-transcriptional modification. This modification is dynamically and reversibly regulated by methyltransferases and demethylases, and is involved in regulating biological effects through m6A binding proteins. Recent studies have elucidated that m6A is involved in embryonic skin morphogenesis, wound repair, and pathophysiological processes such as inflammatory response, angiogenesis, and fibrosis. This review summarizes the role of m6A and its related proteins in the related pathophysiological processes of wound repair, so as to provide a new theoretical basis for the treatment strategy of wound repair.
