Research advances on the application of natural and recombinant collagen in wound repair.
10.3760/cma.j.cn501120-20211123-00394
- Author:
Xiao Gang LIU
1
;
Lei CHEN
1
;
Hai Hang LI
2
;
Yan Ke HU
1
;
Ya Hui XIONG
1
;
Wei HUANG
1
;
Sha Sha SU
3
;
Shao Hai QI
1
Author Information
1. Department of Burn and Wound Repair, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510062, China.
2. School of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
3. Sun Yat-sen University-Yixian Group Skin Health Precision Research Joint Laboratory, Yue Keli Skin Regeneration Laboratory, Guangzhou 510275, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Collagen/metabolism*;
Wound Healing;
Tissue Engineering;
Tissue Scaffolds;
Cosmetics;
Mammals/metabolism*
- From:
Chinese Journal of Burns
2022;38(10):978-982
- CountryChina
- Language:Chinese
-
Abstract:
Collagen is a macromolecular protein constituting the extracellular matrix of animal connective tissue, which has been widely used and developed in fields of biomedicine, tissue engineering, food, and cosmetics. Due to its advantages such as abundant sources and good biocompatibility, low immunogenicity, and degradability, collagen can be used as a dressing or tissue engineering scaffold for wound repair. According to the source of materials, collagen can be divided into natural collagen and recombinant collagen. Natural collagen is mainly extracted directly from mammals and fish; recombinant collagen is obtained based on genetic engineering technology, and its sources include recombinant expression systems of microorganisms, animals, and plants. This paper summarizes the sources of collagen, and the roles, advantages, and disadvantages of different sources of collagen in wound repair, the particularity and superiority of collagen combined with three-dimensional printing technology in wound repair, the impact of market norms of China's collagen industry on the field of wound repair, and explains the precautions for the development of collagen-related products, aiming to provide new ideas for selecting a suitable source of collagen for wound repair.
