In situ monitoring and regulation of local reactive oxygen species levels to promote wound repair.
10.3760/cma.j.cn501225-20220720-00299
- Author:
Gao Xing LUO
1
;
Jun DENG
1
Author Information
1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Reactive Oxygen Species;
Wound Healing/physiology*;
Oxidative Stress/physiology*;
Inflammation
- From:
Chinese Journal of Burns
2022;38(10):899-904
- CountryChina
- Language:Chinese
-
Abstract:
Local oxidative stress and inflammatory response are the essential procedures in wound repair, which determine the progress, prognosis, and quality of wound repair. Reactive oxygen species is one of the important indexes reflecting oxidative stress and inflammatory response of body, which is considered as a promising target to be regulated in wound inflammation. Recently, with the rapid development of nanomedicine, our research group and other research groups have successfully developed various diagnosis and treatment reagents for reactive oxygen species through interdisciplinary integration, to monitor and regulate reactive oxygen species in wounds in real time, and to finally achieve the goal of improving the speed and quality of wound repair, thus providing a new strategy and direction for the diagnosis and treatment of local inflammatory response in wounds. This article summarizes reactive oxygen species as the regulatory target of local inflammatory response in wounds, in situ monitoring and precise regulation of reactive oxygen species.
