Research advances on the function of skin touch receptor Merkel cells.
10.3760/cma.j.cn501120-20211209-00409
- Author:
Hui Pu YUAN
1
;
Yuan Yuan DING
1
;
Yi Xi ZHENG
1
;
Ya Jun ZHANG
1
;
Xia LIU
2
;
Chen RUI
1
;
Chao Chen WANG
3
;
Ying XIAO
1
Author Information
1. Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, China.
2. Centre for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
3. Union College of Edinburgh University, Zhejiang University, Haining 314400, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Ion Channels/metabolism*;
Mechanotransduction, Cellular/physiology*;
Merkel Cells/physiology*;
Skin/metabolism*;
Touch/physiology*
- From:
Chinese Journal of Burns
2022;38(9):887-892
- CountryChina
- Language:Chinese
-
Abstract:
The reconstruction of tactile function during the repair of skin damage caused by factors including burns is inseparable from the functional regeneration of tactile receptor Merkel cells. Merkel cells mainly exist in the basal layer of the epidermis and are closely connected with nerves to form Merkel cell-nerve complexes, which play an important role in biological organisms. A large number of studies have shown that Merkel cells conduct precise transmission of mechanical force stimuli through the mechanically gated ion channels PIEZO2, and perform the function of tactile receptors. In this paper, we discussed the characteristics of Merkel cells and analyzed the different subgroups that may possibly exist in this type of cells and their functions, at the same time, we investigated the animal model research of touch-related diseases and the clinical diseases related to touch, revealing the importance of Merkel cell function research.
