Research advances on interleukin-6 in hypertrophic scar formation.
10.3760/cma.j.cn501120-20210331-00111
- VernacularTitle:白细胞介素6在增生性瘢痕形成中的作用研究进展
- Author:
Zu Han CHEN
1
;
Bin YU
1
;
Qi Fa YE
1
;
Yan Feng WANG
1
Author Information
1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, China.
- Publication Type:Review
- MeSH:
Cicatrix, Hypertrophic/pathology*;
Endothelial Cells/metabolism*;
Fibroblasts/metabolism*;
Humans;
Interleukin-6;
Skin/pathology*;
Wound Healing/physiology*
- From:
Chinese Journal of Burns
2022;38(9):874-877
- CountryChina
- Language:Chinese
-
Abstract:
Hypertrophic scar is a pathological repair result of excessive accumulation of extracellular matrix after skin damage, which affects the appearance and function of patients with varying degrees. The degree of scar formation is directly related to the strength of inflammatory reaction during wound healing, and excessive or prolonged inflammatory response increases the incidence of hypertrophic scars. Interleukin-6 (IL-6) is a pleiotropic cytokine that is involved in regulating the fibrotic network composed of fibroblasts, macrophages, keratinocytes, and vascular endothelial cells, and is closely related to the formation of hypertrophic scars. This article reviews the role of IL-6 and its signaling pathway in hypertrophic scar formation.
