Research progress of induced pluripotent stem cells in promoting wound healing of diabetic foot ulcers.
10.3760/cma.j.cn501120-20210630-00230
- Author:
Chun Chen GAO
1
;
Jin An CHEN
1
;
Ai Ping WANG
1
Author Information
1. Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Diabetic Foot Center, Nanjing 210002, China.
- Publication Type:Review
- MeSH:
Animals;
Diabetes Mellitus;
Diabetic Foot/drug therapy*;
Induced Pluripotent Stem Cells;
Wound Healing
- From:
Chinese Journal of Burns
2022;38(9):864-869
- CountryChina
- Language:Chinese
-
Abstract:
Chronic wounds such as diabetic foot ulcers are epidemic, which bring huge burdens to both the patients and the society. However, with current treatment methods, diabetic foot ulcers often heal poorly and recur frequently, so it is urgent and important to find new and advanced therapies. Stem cell therapy has been proved by a large number of pre-clinical and clinical studies as a potential treatment for chronic wounds. However, the acquisition of stem cells often depends on invasive techniques, and immunogenicity and limited cell survival in vivo also limit the large-scale application and promotion of stem cell therapy. In the recent years, with the development and advance of induced pluripotent stem cell (iPSC) technology, it has shown a strong translational potential in the treatment of chronic wounds such as diabetic foot ulcers. This article reviews the applications and prospect of iPSCs in animal wound healing models including diabetic ulcers and limb ischemia, the limitations of their clinical application, and the methods to improve their safety.
