Research advances on the role of acid fibroblast growth factor in promotion of wound healing.
10.3760/cma.j.cn501120-20210811-00276
- VernacularTitle:酸性成纤维细胞生长因子在促进创面愈合中的作用研究进展
- Author:
Hong Tao WANG
1
;
Jun Tao HAN
1
;
Da Hai HU
1
Author Information
1. Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.
- Publication Type:Journal Article
- MeSH:
Collagen;
Extracellular Matrix;
Fibroblast Growth Factor 1;
Humans;
Neovascularization, Pathologic;
Wound Healing/physiology*
- From:
Chinese Journal of Burns
2022;38(9):859-863
- CountryChina
- Language:Chinese
-
Abstract:
Acid fibroblast growth factor (aFGF) is a member of fibroblast growth factors (FGF) family, widely promoting embryonic development, wound healing, vascular regeneration, nerve injury repair, as well as regulating immune metabolism. Many pathophysiological processes, such as inflammation, neovascularization, proliferation and migration of repair cells, and deposition of collagen and other extracellular matrix are involved in the process of wound healing. Based on the relevant literature in recent years, this article mainly reviews the research progresses on the roles and mechanism of aFGF in biological signal transduction, regulation of cell growth, and involvement in tissue repair, and discusses the current research hot spots as well as the prospective future direction of clinical applications of aFGF in the aspect of clinical pharmacokinetics and safety.
