Research advances on the role and mechanism of epidermal stem cells in skin wound repair.
10.3760/cma.j.cn501120-20211109-00382
- VernacularTitle:表皮干细胞在皮肤创面修复中的作用与机制研究进展
- Author:
Zhi Yuan SHI
1
;
Bo Han ZHANG
1
;
Jia Chen SUN
1
;
Xin Zhu LIU
1
;
Zhuan An SHEN
1
Author Information
1. Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
- Publication Type:Review
- MeSH:
Epidermal Cells/physiology*;
Epidermis;
Humans;
Re-Epithelialization;
Skin;
Soft Tissue Injuries;
Stem Cells
- From:
Chinese Journal of Burns
2022;38(9):854-858
- CountryChina
- Language:Chinese
-
Abstract:
Epidermal stem cells play an pivotal role in skin self-renewal, wound repair, and re-epithelialization process. The emergence of new technologies and concepts such as single-cell sequencing and gene knockout further revealed a new mechanism of epidermal stem cells in epidermal self-renewal and wound repair, providing new ideas for wound repair. In this review, the mechanisms of proliferation, differentiation, and migration of epidermal stem cells are discussed. Combined with the analysis of researches on stem cell heterogeneity and cell plasticity, the physiological function of epidermal stem cells can be further understood. The application advances of epidermal stem cells in wound repair is also summarized, which would provide some advice for workers engaged in clinical and basic research on wound repair.
