Research advances on the interaction between Pseudomonas aeruginosa bacteriophages and the host.
10.3760/cma.j.cn501120-20210929-00338
- Author:
Xi SHI
1
;
Zhuo ZENG
2
;
Yi Ming ZHANG
1
;
Zi Chen YANG
1
;
Yi Zhi PENG
2
Author Information
1. Department of Plastic and Cosmetic Surgery, the Second Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400037, China.
2. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.
- Publication Type:Review
- MeSH:
Bacteriophages;
Burns/therapy*;
Humans;
Pseudomonas Infections/microbiology*;
Pseudomonas Phages;
Pseudomonas aeruginosa;
Virulence Factors
- From:
Chinese Journal of Burns
2022;38(9):849-853
- CountryChina
- Language:Chinese
-
Abstract:
Pseudomonas aeruginosa is the most common pathogen of burn wound infection. It can encode a variety of virulence factors and is highly pathogenic, which can lead to poor prognosis and high mortality. In order to research a new method to combat Pseudomonas aeruginosa infection, researchers have observed a wide range of interactions between the bacteriophages and the host. Bacteriophages influence and even dominate the structure, movement, and metabolism of host bacteria through a variety of mechanisms, catalyze the evolution of the host, and are also an important factor in host environmental adaptability and pathogenicity. In this paper, the interaction between Pseudomonas aeruginosa bacteriophages and the host is reviewed from the single cell level and the population level. Understanding these interactions could provide new idea for the treatment of Pseudomonas aeruginosa clinical infections, provides a basis for future development of antimicrobial agents and guides the treatment of burn infections.
