Analysis of pathogenic bacteria in cirrhotic patients complicated with bacterial infection in a tertiary hospital in Xinjiang.
10.3760/cma.j.cn501113-20201224-00677
- Author:
Dan TANG
1
;
Bieerding MAIHEBUBA
1
;
Xiao Feng SUN
1
;
Xiao Bi LU
1
Author Information
1. Department of Infection Disease, The First Affiliated Hospital of Xinjiang Medical University & Xinjiang Infectious Diseases (Viral Hepatitis) Clinical Medical Research Center, Wulumuqi 830054, China.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents/therapeutic use*;
Bacteria;
Bacterial Infections/epidemiology*;
Drug Resistance, Bacterial;
Escherichia coli;
Glucose;
Humans;
Liver Cirrhosis/drug therapy*;
Microbial Sensitivity Tests;
Retrospective Studies;
Tertiary Care Centers
- From:
Chinese Journal of Hepatology
2022;30(8):885-888
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the species, distribution, and extent of drug resistance of pathogenic bacteria in patients with liver cirrhosis combined with bacterial infection in a tertiary hospital in Xinjiang. Methods: 1 271 cases with liver cirrhosis combined with infection were analyzed retrospectively for pathogenic bacterial species and drug resistance condition in different bacterial strain. Results: Among the 1 271 cases with liver cirrhosis, 480 were combined with infection, and the infection rate was 37.8%. The majority of infected patients had decompensated cirrhosis (438 cases). Peritoneum (327 cases, 60.8%) was the common infection site, followed by lungs (16.9%). 343 strains of pathogens were isolated from 480 infected cases, of which 289 strains were among the top 10 common distinct bacteria, accounting for 76.5% and 23.5% of Gram-negative and positive bacteria. The first top three strains were Escherichia coli. (33.2%), Klebsiella pneumoniae (11.4%), and Enterococcus faecium (11.1%), and there were differences in the drug resistance rates of each strain. Conclusion: In a tertiary hospital in Xinjiang, patients with decompensated cirrhosis have a high rate of bacterial infection. The pathogenic bacteria are diverse, mainly Gram-negative bacteria; however, the infection rate of Gram-positive bacteria such as Enterococcus is gradually increasing. Additionally, according to the bacterial properties, they are divided into four categories: Enterobacter, Enterococcus, glucose non-fermenting bacteria and Staphylococcus, and it is found that even the same species of bacteria have different drug resistance rates.
