Research advances of metabolomics in early diagnosis of hepatocellular carcinoma.
10.3760/cma.j.cn501113-20220624-00346
- Author:
Xing Mei LIAO
1
;
Si Ru ZHAO
2
;
Wen Cong DAI
3
;
Rong FAN
3
Author Information
1. Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
2. The first School of Clinical Medicine, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou 510515, China.
3. Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China The first School of Clinical Medicine, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou 510515, China.
- Publication Type:Review
- MeSH:
Biomarkers, Tumor;
Carcinoma, Hepatocellular/pathology*;
Early Detection of Cancer;
Humans;
Liver Neoplasms/pathology*;
Metabolomics/methods*
- From:
Chinese Journal of Hepatology
2022;30(8):803-808
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer is the second leading cause of death from malignant tumors in China, and hepatocellular carcinoma (HCC) is the main type. The disease stage at the time of HCC diagnosis largely determines the efficacy of subsequent treatment. Due to the HCC screening among high-risk population has not yet popularized, and the current diagnose method of early HCC is not satisfactory, the early HCC diagnosis rate is less than 30% in China. Metabolomics research emerging in recent years has promoted the research progress of HCC in many fields, such as elaborating the mechanism of occurrence and development, early prevention and diagnosis, exploring drug treatment targets. At the same time, a large number of serum metabolites with excellent sensitivity and specificity were discovered, which made up for the deficiency of traditional serological indicators and helped the early screening and early diagnosis of HCC. This review will summarize the studies on serum metabolomic markers of HCC in recent 5 years, explore the role of metabolomics in the early prediction and diagnosis of HCC and its application prospect.
