Advances of enhancers in regulating craniomaxillofacial development in mammals.
10.3760/cma.j.cn112144-20211022-00471
- Author:
Hao LIU
1
;
Jie Wen DAI
2
;
Gang DING
3
Author Information
1. School of Stomatology, Weifang Medical University, Weifang 261053, China.
2. Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
3. Department of Oral and Maxillofacial, School of Stomatology, Weifang Medical University, Weifang 261053, China.
- Publication Type:Systematic Review
- MeSH:
Animals;
Enhancer Elements, Genetic;
Mammals/genetics*
- From:
Chinese Journal of Stomatology
2022;57(9):978-982
- CountryChina
- Language:Chinese
-
Abstract:
As a key regulatory element of gene differential expression, enhancer plays a crucial role in craniomaxillofacial development through regulating the spatiotemporal expression of target genes to promote tissue-specific differentiation. With the development of CRISPR and chromosome conformation capture technique, the function of enhancer and its regulatory mechanism has been explored in depth. This paper gave a systematic review on the mechanism of enhancer regulating target gene expression and the role of enhancer in oral craniofacial development and malformation.
