Comparison of high-flow nasal cannula oxygen therapy and non-rebreather face mask in the treatment of mild carbon monoxide poisoning.
10.3760/cma.j.cn121094-20211025-00513
- Author:
Wan Na DONG
1
;
Bing Xia WANG
2
;
Peng CAO
2
;
Qing Cheng ZHU
2
;
Ding Yu TAN
2
;
Bing Yu LING
2
Author Information
1. Emergency Department, The Yangzhou School of Clinical Medicine of Dalian Medical University, Northern Jiangsu People's Hospital, Yangzhou 225001, China Graduate School of Dalian Medical University, Dalian 116044, China.
2. Emergency Department, The Yangzhou School of Clinical Medicine of Dalian Medical University, Northern Jiangsu People's Hospital, Yangzhou 225001, China.
- Publication Type:Journal Article
- Keywords:
Carbon monoxide poisoning;
Carboxyhemoglobin;
Cohort studies;
Half-life;
High-flow nasal cannula oxygen therapy;
Non-rebreather face mask
- MeSH:
Humans;
Carbon Monoxide Poisoning/therapy*;
Cannula;
Respiration, Artificial;
Masks;
Oxygen Inhalation Therapy/methods*;
Carboxyhemoglobin;
Oxygen/therapeutic use*;
Respiratory Insufficiency/therapy*
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2022;40(10):771-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the efficacy of high-flow nasal cannula oxygen therapy (HFNC) and non-rebreather face mask (NRFM) in the treatment of mild acute carbon monoxide poisoning (ACOP) in reducing carboxyhemoglobin (COHb) , and to explore the feasibility of HFNC in the treatment of ACOP. Methods: Patients with mild ACOP with COHb >10% who were admitted to the emergency department of Northern Jiangsu People's Hospital from January 2015 to December 2020 were analyzed, and those with altered consciousness, mechanical ventilation and those requiring hyperbaric oxygen therapy were excluded. The patients were divided into HFNC group and NRFM group according to the oxygen therapy used in the emergency department. The COHb decline value and COHb half-life in the two groups were observed. Results: Seventy-one patients were enrolled, including 39 in the NRFM group and 32 in the HFNC group. The baseline COHb in the HFNC group was 24.8%±8.3%, and that in the NRFM group was 22.5%±7.1%, with no significant difference between the two groups (t=1.27, P=0.094) . At 60 min, 90 min and 120 min of treatment, COHb in both groups decreased, but the COHb in HFNC group was lower than that in NRFM group at the same time point (P<0.05) . After 1 h of treatment, the COHb decrease in the HFNC group (16.9%±4.5%) was significantly higher than that in the NRFM group (10.1%±7.8%) (t=4.32, P=0.013) . The mean half-life of COHb in the HFNC group (39.3 min) was significantly lower than that in the NRFM group (61.4 min) (t=4.69, P=0.034) . Conclusion: HFNC treatment of mild ACOP can rapidly reduce blood COHb level, it is a potential oxygen therapy method for clinical treatment of ACOP.
