Management and short-term outcomes of neonates born to mothers infected with SARS-CoV-2 Omicron variant.
10.3760/cma.j.cn112140-20220613-00545
- Author:
Shu Juan LI
1
;
Lan ZHANG
1
;
Hao YUAN
1
;
Xiao Bo ZHANG
2
;
Chuan Qing WANG
3
;
Gong Bao LIU
4
;
Ying GU
5
;
Tong Ling YANG
1
;
Xiao Ting ZHU
1
;
Xiao Wen ZHAI
6
;
Yu SHI
7
;
Si Yuan JIANG
1
;
Ke ZHANG
1
;
Kai YAN
1
;
Peng ZHANG
1
;
Xiao Jing HU
5
;
Qing LIU
1
;
Rui Wei GAO
1
;
Juan ZHAO
8
;
Jian Guo ZHOU
1
;
Yun CAO
1
;
Zhi Hua LI
1
Author Information
1. Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
2. Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
3. Department of Infectious Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
4. Department of Medical Affairs, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
5. Department of Nursing, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
6. Department of Hematology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
7. Department of Rheumatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
8. Department of Neonatology, Shanghai Public Health Clinical Center, Shanghai 201508, China.
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Infant;
Infant, Newborn;
Male;
Pregnancy;
COVID-19;
Mothers;
Pregnancy Complications, Infectious/prevention & control*;
Retrospective Studies;
SARS-CoV-2
- From:
Chinese Journal of Pediatrics
2022;60(11):1163-1167
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize the management and short-term outcomes of neonates delivered by mothers infected with SARS-CoV-2 Omicron variant. Methods: A retrospective study was performed on 158 neonates born to mothers infected with SARS-CoV-2 Omicron variant admitted to the isolation ward of Children's Hospital of Fudan University from March 15th, 2022 to May 30th, 2022. The postnatal infection control measures for these neonates, and their clinical characteristics and short-term outcomes were analyzed. They were divided into maternal symptomatic group and maternal asymptomatic group according to whether their mothers had SARS-CoV-2 symptoms. The clinical outcomes were compared between the 2 groups using Rank sum test and Chi-square test. Results: All neonates were under strict infection control measures at birth and after birth. Of the 158 neonates, 75 (47.5%) were male. The gestational age was (38+3±1+3) weeks and the birth weight was (3 201±463)g. Of the neonates included, ten were preterm (6.3%) and the minimum gestational age was 30+1 weeks. Six neonates (3.8%) had respiratory difficulty and 4 of them were premature and required mechanical ventilation. All 158 neonates were tested negative for SARS-COV-2 nucleic acid by daily nasal swabs for the first 7 days. A total of 156 mothers (2 cases of twin pregnancy) infected with SARS-CoV-2 Omicron variant, the time from confirmed SARS-CoV-2 infection to delivery was 7 (3, 12) days. Among them, 88 cases (56.4%) showed clinical symptoms, but none needed intensive care treatment. The peripheral white blood cell count of the neonates in maternal symptomatic group was significantly higher than that in maternal symptomatic group (23.0 (18.7, 28.0) × 109 vs. 19.6 (15.4, 36.6) × 109/L, Z=2.44, P<0.05). Conclusions: Neonates of mothers infected with SARS-CoV-2 Omicron variant during third trimester have benign short-term outcomes, without intrauterine infection through vertical transmission. Strict infection control measures at birth and after birth can effectively protect these neonates from SARS-CoV-2 infection.
