Clinical characteristics of convalescent children infected with SARS-CoV-2 Omicron variant in Tianjin.
10.3760/cma.j.cn112140-20220711-00631
- Author:
Yan SUN
1
;
Bing WANG
1
;
Ze Hua ZHANG
2
;
Guo Feng ZHANG
3
;
Xue WANG
2
;
Zhang Jie WANG
1
;
Dan Yang LI
1
;
Jingxiao ZHANG
1
Author Information
1. Department of Surgical Intensive Care Unit, Tianjin First Central Hospital, Tianjin 300192, China.
2. Tianjin Key Laboratory of Organ Transplantation, Tianjin 300192, China.
3. Department of Pediatric Transplantation, Tianjin First Central Hospital, Tianjin 300192, China.
- Publication Type:Journal Article
- MeSH:
Antibodies, Viral;
COVID-19/therapy*;
COVID-19 Vaccines;
Child;
Female;
Humans;
Immunoglobulin G;
Immunoglobulin M;
Male;
Nucleic Acids;
Retrospective Studies;
SARS-CoV-2
- From:
Chinese Journal of Pediatrics
2022;60(10):1054-1058
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the clinical characteristics of SARS-CoV-2 Omicron variant infected children in convalescence in Tianjin. Methods: A total of 104 pediatric patients infected by SARS-CoV-2 Omicron variant Tianjin First Central Hospital (designated hospital for SARS-CoV-2 infection in Tianjin) for convalescent treatment from January 22nd, 2022 to February 24th were included for a retrospective study.Clinical data including clinical typing, SARS-CoV-2 IgG and IgM test and 2019-nCoV nucleic acid test were collected.The cases were divided into 2-dose group and zero-dose group based on the doses of inactivated SARS-CoV-2 vaccine. The children were divided into repositive group and negative group, according to the nucleic acid test during hospitalization. Chi-square test was used for the comparison between the groups. Results: The age of these 104 children was 10.0 (0.3, 14.0) years on admission, 53 children were males and 51 were females, 92 cases (88.5%) had mild symptoms, 12 cases (11.5%) had common symptoms.The age and SARS-CoV-2 IgG level of zero-dose group was lower (2.0 (0.3, 10.2) vs. 10.0 (3.2, 14.0) years, 10 (2, 17) vs. 193 (157, 215), χ²=-5.57, Z=-48.76,both P<0.001) than that of 2-dose group. The zero-dose group had a high rate of transmission among family members and a high level of SARS-CoV-2 IgM level (13/14 vs. 62.2% (56/90), 0.4 (0.2, 0.8) vs. 0.4 (0.2, 1.1),χ²=5.09, Z=-48.95, both P<0.05) than the 2-dose group. Repositive group had a high rate of underlying diseases and SARS-CoV-2 IgM level was higher (2/13) vs. 1.1% (1/91), (0.6 (0.2, 1.0) vs. 0.3 (0.2, 0.7), χ²=8.29, Z=2.70, both P<0.05) than negative group. The SARS-CoV-2 IgG level of repositive group was lower than that of negative group (160 (78, 197) vs. 213 (186, 231), χ²=-3.20, P<0.05). Conclusions: Children infected with SARS-CoV-2 Omicron variant in Tianjin were mainly transmitted by family members, and most of them had mild symptoms. Two-dose group had higher IgG levels and lower IgM levels than zero-dose group.The probability of SARS-CoV-2 nucleic acid test repositivity increased in children with underlying diseases and lower IgG levels.
