Clinical phenotypes and genotypic spectrum of cystic fibrosis with pancreatic insufficiency in children.
10.3760/cma.j.cn112140-20220427-00384
- VernacularTitle:囊性纤维化患儿合并胰腺外分泌不全临床特征及基因型分析
- Author:
Zhuo Yao GUO
1
;
Jing Long CHEN
1
;
Li Bo WANG
1
;
Li Ling QIAN
1
Author Information
1. Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
- Publication Type:Journal Article
- MeSH:
Cystic Fibrosis/genetics*;
Diarrhea/complications*;
Exocrine Pancreatic Insufficiency/genetics*;
Female;
Genotype;
Humans;
Male;
Malnutrition/complications*;
Pancreatic Diseases/genetics*;
Phenotype;
Retrospective Studies;
Steatorrhea/genetics*
- From:
Chinese Journal of Pediatrics
2022;60(9):915-919
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical phenotypes and genotypic spectrum of exocrine pancreatic insufficiency in children with cystic fibrosis. Methods: This was a retrospective analysis of 12 children with cystic fibrosis who presented to Children's Hospital of Fudan University from December 2017 to December 2021. Clinical features, fecal elastase-1 level, genotype, diagnosis and treatment were systematically reviewed. Results: A total of 12 children, 7 males and 5 females, diagnosis aged 5.4 (2.0, 10.6) years, were recruited. Common clinical features included chronic cough in 12 cases, malnutrition in 7 cases, steatorrhea in 7 cases, bronchiectasis in 5 cases and electrolyte disturbance in 4 cases. Exocrine pancreatic insufficiency were diagnosed in 8 cases,the main clinical manifestations were steatorrhea in 7 cases, of which 5 cases started in infancy; 6 cases were complicated with malnutrition, including mild in 1 case, moderate in 2 cases and severe in 3 cases; 3 cases had abdominal distension; 2 cases had intermittent abdominal pain; 4 cases showed fatty infiltration or atrophy of pancreas and 3 cases showed no obvious abnormality by pancreatic magnetic resonance imaging or B-ultrasound. All 8 children were given pancreatic enzyme replacement therapy, follow-up visit of 2.3 (1.2,3.2) years. Diarrhea significantly improved in 6 cases, and 1 case was added omeprazole due to poor efficacy. A total of 20 variations of CFTR were detected in this study, of which 7 were novel (c.1373G>A,c.1810A>C,c.270delA,c.2475_2478dupCGAA,c.2489_c.2490insA, c.884delT and exon 1 deletion). Conclusions: There is a high proportion of exocrine pancreatic insufficiency in Chinese patients with cystic fibrosis. The main clinical manifestations are steatorrhea and malnutrition. Steatorrhea has often started from infancy. Pancreatic enzyme replacement therapy can significantly improve the symptoms of diarrhea and malnutrition.
