Research progress of mesenchymal stem cell in the treatment of diabetic bladder dysfunction.
10.3760/cma.j.cn112139-20220530-00245
- Author:
Cong MA
1
;
Yi Jun CHENG
1
;
Nan XIAO
1
Author Information
1. Department of Urology, Lanzhou University Sencond Hospital, Key Laboratory of Gansu Province for Urological Diseases, Gansu Nephro-Urological Clinical Center, Lanzhou 730030, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Urinary Bladder;
Mesenchymal Stem Cells;
Diabetes Mellitus/metabolism*
- From:
Chinese Journal of Surgery
2022;60(11):1035-1040
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic bladder dysfunction (DBD) is a common complication in the lower urinary tract of diabetes. In recent years, mesenchymal stem cell (MSC) have broad application prospects in the treatment of DBD. MSC can migrate to damaged bladder tissue and differentiate into various cell types, such as urothelial cells, myofibroblasts, smooth muscle cells and nerve cells, promote bladder tissue repair and regeneration through paracrine effects. In addition, MSC also intervene in the pathological process of DBD, reverse disease progression, and restore partial bladder function through immune regulation, improvement of oxidative stress, and regulation of blood glucose. At present, the treatment of DBD with MSC is limited to preclinical animal experiments, clinical research and application should be pursued further.
