Complicated lymphatic anomaly: a clinicopathological analysis of four cases.
10.3760/cma.j.cn112151-20220825-00728
- VernacularTitle:复杂性淋巴管异常4例临床病理学分析
- Author:
Bo Ju PAN
1
;
Da Chun ZHAO
1
;
Wei Xun ZHOU
1
;
Rui E FENG
1
Author Information
1. Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Male;
Humans;
Female;
Child;
Adolescent;
Young Adult;
Adult;
Osteolysis, Essential/pathology*;
Lymphatic Abnormalities/surgery*;
Bone and Bones/pathology*;
Diagnosis, Differential;
Prognosis
- From:
Chinese Journal of Pathology
2022;51(11):1147-1151
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinicopathological features, clinical manifestations and different diagnosis of patients with complicated lymphatic anomaly. Methods: The clinical and pathologic data of four patients with complicated lymphatic anomaly diagnosed and treated in Peking Union Medical College Hospital from January 2000 to December 2021 were collected and analyzed. Results: One Gorham-Stout disease case and three generalized lymphatic anomaly cases were included in this cohort. Patients' ages ranged from 7 to 32 years. There were three males and one female. The positions of biopsy included three bone biopsy and one bronchus biopsy. Microscopically, all cases showed diffuse enlarged lymphatic channels. At the same time, osteogenesis was obvious in Gorham-Stout disease case. Radiologically, cortical loss was seen in Gorham-Stout disease, and lytic bone confined to the medullary cavity presented in generalized lymphatic anomaly. The three generalized lymphatic anomaly cases also had coagulopathy, and two had effusion. Conclusions: The histologic feature of complicated lymphatic anomaly was diffuse lymphatic malformation, and the diagnosis depends on clinical and pathologic information. The treatment and prognosis of these diseases are different, and therefore it is necessary to understand their clinical and pathologic features and make the correct diagnosis.
