Circulating levels of interleukin-8 and vascular endothelial growth factor in patients with carotid stenosis.
10.3346/jkms.2001.16.2.198
- Author:
Sang Hwa LEE
1
;
Min Ho JEONG
;
Hae Rhan BAE
;
Soo Jin JEONG
;
Ji Yeon JANG
;
Yeong Jin LIM
;
Sang Ho KIM
;
Jae Woo KIM
;
Jae Kwan CHA
Author Information
1. Institute of Medical Science, School of Medicine, Dong-A University, Pusan, Korea. nrcjk@unitel.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Atherosclerosis;
Endothelial Growth Factors;
Interleukin-8;
Endothelium, Vascular;
Carotid Stenosis
- MeSH:
Adult;
Aged;
Carotid Artery Diseases/blood;
Carotid Stenosis/*blood;
Disease Progression;
Endothelial Growth Factors/*blood;
Female;
Human;
Interleukin-8/*blood;
Lymphokines/*blood;
Male;
Middle Age
- From:Journal of Korean Medical Science
2001;16(2):198-203
- CountryRepublic of Korea
- Language:English
-
Abstract:
Interleukin (IL)-8 and vascular endothelial growth factor (VEGF) are important factors that induce the migration and proliferation of endothelial cells, increase the vascular permeability, and the modulate chemotaxis of monocytes. These molecules have been found in human atherosclerotic plaques. However, it is not clear whether the circulating levels of IL-8 and VEGF correlate with the extents of carotid stenosis. In this study, we investigated the relationship between circulating levels of IL-8 as well as VEGF and the extents of carotid stenosis. Sera from 41 patients with carotid stenosis were assessed for concentrations of IL-8 and VEGF by enzyme-linked immunosorbent assay. The degree of stenosis of extracranial carotid artery was calibrated by carotid B- mode ultrasonography. The serum concentration of IL-8 (r=-0.04733, p>0.05) was not correlated with the degree of stenosis. However, the serum concentration of VEGF (r=0.4974, p<0.01) was significantly correlated with the degree of carotid stenosis. These findings suggest that increased serum level of VEGF might be a marker for higher degree of stenosis of extracranial carotid artery.
