Myxiod pleomorphic liposarcoma: a clinicopathological and molecular genetic analysis of six cases.
10.3760/cma.j.cn112151-20220524-00441
- Author:
Xin Chun ZHENG
1
;
Hai Jian HUANG
2
;
Zhi Jie YOU
3
;
Jie LIN
2
;
Xiao Yan CHEN
2
;
Dingrong ZHONG
4
Author Information
1. Department of Pathology, Xiamen Third Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen 361100, China Department of Pathology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, China.
2. Department of Pathology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, China.
3. Department of Pathology, Fujian Provincial Hospital South Branch, Fuzhou 350028, China.
4. Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Immunohistochemistry;
In Situ Hybridization, Fluorescence;
Liposarcoma/pathology*;
Liposarcoma, Myxoid/diagnosis*;
Male;
Molecular Biology;
Proto-Oncogene Proteins c-mdm2/genetics*;
Translocation, Genetic
- From:
Chinese Journal of Pathology
2022;51(8):738-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinicopathologic and molecular genetic characteristics of myxoid pleomorphic liposarcoma (MPLPS). Methods: Six cases of MPLPS diagnosed and consulted in Fujian Provincial Hospital from 2015 to 2021 were collected for histomorphological observation, immunohistochemistry, and fluorescence in situ hybridization (FISH) detection of DDIT3 (CHOP) gene translocation and MDM2/CDK4 gene amplification. Results: There were four males and two females, aged 26-74 years (mean 53.8 years). The tumor size was 3.8-16.0 cm (mean 11.8 cm). All six cases had similar histopathologic features, showing overlapping histologic morphology of myxoid liposarcoma and pleomorphic liposarcoma. Four cases (4/6) were positive for S-100 protein, and the Ki-67 index was 50%-95%. All cases (6/6) were negative for DDIT3 (CHOP) translocation and MDM2/CDK4 amplification by FISH. TP53 (p.R248w) germline mutation was found in one case. Conclusions: MPLPS is a rare subtype of liposarcoma, characterized by overlapping morphology of myxoid liposarcoma and pleomorphic liposarcoma. Genetically, a few of them have TP53 gene germline mutations, but they lack of DDIT3 (CHOP) translocation or MDM2/CDK4 amplification.
