Independent and combined effects of pre-pregnancy BMI and gestational diabetes on early adiposity rebound timing in children.
10.3760/cma.j.cn112338-20220429-00364
- Author:
Shi Qi FAN
1
;
Shuang Qin YAN
2
;
Bei Bei ZHU
1
;
Xiao Zhen LI
1
;
Juan TONG
1
;
Chun Gang LI
1
;
Hui CAO
3
;
Xiao Yan WU
1
;
Liang Liang XIE
3
;
Zhao Lian WEI
1
;
Fangbiao TAO
1
Author Information
1. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Key Laboratory of Population Health Across Life Cycle, Ministry of Education/Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, National Health Commission, Hefei 230032, China.
2. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University/Key Laboratory of Population Health Across Life Cycle, Ministry of Education/Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, National Health Commission, Hefei 230032, China Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China.
3. Maternal and Child Health Care Center of Ma'anshan, Ma'anshan 243000, China.
- Publication Type:Journal Article
- MeSH:
Child;
Infant;
Female;
Pregnancy;
Humans;
Adiposity;
Diabetes, Gestational/epidemiology*;
Overweight/epidemiology*;
Thinness;
Cohort Studies;
Body Mass Index;
Obesity
- From:
Chinese Journal of Epidemiology
2022;43(10):1626-1631
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine the independent and combined effects of pre-pregnancy BMI and gestational diabetes (GDM) on early adiposity rebound (AR) timing in children. Methods: Based on the "Ma'anshan Birth Cohort Study", 2 896 eligible maternal and infant pairs were recruited. In the cohort, we collected pre-pregnancy height, weight, 24 to 28 weeks GDM diagnosis, follow-up at 42 days, three months, six months, nine months of age, and every six months after one year of age, and continuously followed up to 6 years old, and obtained the child's length/height, weight, and other data. The intensity of the association between pre-pregnancy BMI, GDM, and early AR timing was analyzed by the multivariate logistic regression model. Multiplication and additive models were used to analyze how pre-pregnancy BMI and GDM influenced early AR timing in children. Results: The prevalence of underweight, average weight, overweight, and obesity before pregnancy were 23.2% (672), 66.4% (1 923), 8.7% (251), and 1.7% (50). The prevalence of GDM was 12.4%. We found that 39.3% of children had AR, and the average age at AR was (4.38±1.08). The results of multifactorial logistic regression analysis showed that pre-pregnancy overweight (OR=1.67,95%CI:1.27-2.19), pre-pregnancy obesity (OR=3.05,95%CI:1.66-5.56), and maternal GDM (OR=1.40,95%CI:1.11-1.76) were risk factors for early AR timing in children. In contrast, pre-pregnancy underweight (OR=0.60,95%CI:0.49-0.73) was a protective factor for early AR timing in children. Compared with the different effects of pre-pregnancy overweight/obesity and maternal GDM alone, the combined effect caused a higher risk of early AR timing in children, with OR values (95%CI) were 2.03 (1.20-3.44), 3.43 (1.06-11.12), respectively. The multiplication and additive models showed no interaction between pre-pregnancy BMI and GDM-influenced early AR timing in children. Conclusion: Higher pre-pregnancy BMI and maternal GDM are the independent risk factors for the early AR timing in children, and the co-occurrence of the two is higher risks, but there was no statistical interaction.
