Relationship of serum uric acid with prediabetes and newly detected type 2 diabetes mellitus.
10.3760/cma.j.cn112338-20220117-00041
- Author:
Qian WU
1
;
Ying GUAN
2
;
Chun Ze XU
2
;
Na WANG
1
;
Xing LIU
1
;
Feng JIANG
1
;
Qi ZHAO
1
;
Zhong Xing SUN
2
;
Genming ZHAO
1
;
Yonggen JIANG
2
Author Information
1. School of Public Health, Fudan University, Shanghai 200032, China.
2. Songjiang District Center for Disease Control and Prevention of Shanghai, Shanghai 201620, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Male;
Female;
Humans;
Middle Aged;
Aged;
Prediabetic State/epidemiology*;
Uric Acid;
Diabetes Mellitus, Type 2/epidemiology*;
Glycated Hemoglobin;
Fasting
- From:Chinese Journal of Epidemiology
2022;43(10):1603-1610
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the relationship of serum uric acid with prediabetes and newly detected type 2 diabetes mellitus (T2DM) in adults. Methods: Data were obtained from the baseline investigation of Songjiang Peak-Plan cohort. According to the baseline fasting plasma glucose and glycosylated hemoglobin, the eligible subjects were divided into normal blood sugar group, prediabetes group, and newly detected T2DM group. Unconditional logistic regression model was used to explore the effect of serum uric acid level on prediabetes and newly detected T2DM, and restricted cubic spline (RCS) function was used to explore the nonlinear dose-response relationship of serum uric acid level with the prevalence of prediabetes and newly detected T2DM. Results: A total of 30 375 subjects were included in the analysis, with an average age of (55.36±11.52) years, and 60.2% (18 299) of them were women. The baseline survey found that the prevalence of prediabetes was 38.6% (11 739 cases), and the prevalence of newly detected T2DM was 6.6% (1 992 cases). Logistic regression analysis showed that, in women, for every 10µmol/L increase in serum uric acid, the risk of developing prediabetes and T2DM s increased by 2.4% (OR=1.024, 95%CI: 1.018-1.030), and 1.5% (OR=1.015, 95%CI: 1.005-1.025), respectively; in men, for every 10 µmol/L increase in serum uric acid, the risk of developing prediabetes and T2DM decreased by 0.8% (OR=0.992, 95%CI: 0.987-0.998) and 5.0% (OR=0.950, 95%CI: 0.939-0.960), respectively. The RCS function showed that the serum uric acid level showed a nonlinear dose-response relationship with newly detected T2DM (P=0.017), but not with prediabetes (P=0.670) in women and showed a nonlinear dose-response relationship with both prediabetes (P=0.040) and newly detected T2DM (P<0.001) in men. Conclusions: Adult women are at increased risk of prediabetes and newly detected T2DM with increase of serum uric acid level, and adult men are at decreased risk of newly diagnosed T2DM with the increase of serum uric acid level. There was no significant relationship between serum uric acid level and prediabetes in men.
