Association between fasting plasma glucose and mild cognitive impairment in Chinese 55 and older population from four provinces.
10.3760/cma.j.cn112338-20211223-01012
- VernacularTitle:中国4省份55岁及以上中老年人空腹血糖与轻度认知功能障碍的关联研究
- Author:
Xiao Fang JIA
1
;
Zhi Hong WANG
1
;
Fei Fei HUANG
1
;
Wen Wen DU
1
;
Hong Ru JIANG
1
;
Chang SU
1
;
Xiao Feng ZHANG
1
;
Jing BAI
1
;
Bing ZHANG
1
;
Hui Jun WANG
1
Author Information
1. National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention/Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Middle Aged;
Humans;
Aged;
Fasting;
Blood Glucose;
Activities of Daily Living;
Cohort Studies;
Cognitive Dysfunction/epidemiology*;
China/epidemiology*
- From:
Chinese Journal of Epidemiology
2022;43(10):1590-1595
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the association of fasting plasma glucose (FPG) with mild cognitive impairment (MCI) in the Chinese middle-aged and elderly population from four provinces. Methods: Data were drawn from the baseline data of the Community-based Cohort Study on Nervous System Disease 2018-2019. We selected 3 272 subjects aged 55 and above with completed information on demographics, lifestyle, disease history, cognitive test, psychological assessment, and bio-chemistries measurement, and who were capable of performing basic activities of daily living but without Alzheimer's disease during recruitment. A multivariate logistic regression model was employed to analyze the association between FPG and MCI. Results: Median level of FPG in the study population was 5.5 mmol/L. The prevalence of MCI was 24.8%, and those in groups of the FPG quintile were 19.4%, 22.2%, 29.2%, 26.6%, and 26.1%, respectively, which significantly increased the trend (P=0.002). After adjustment of confounders, multivariate logistic regression analysis found that the MCI risk of subjects in the Q3,Q4 and Q5 groups was 1.641 (95%CI: 1.226-2.131), 1.373 (95%CI: 1.036-1.825), 1.402 (95%CI: 1.054-1.871) times as high as that in the Q1 group, respectively. Conclusion: High FPG level might serve as a risk factor for MCI in the middle-aged and elderly population, suggesting the importance of monitoring and controlling plasma glucose even without diabetes.
